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Ashpole Research Lab
University of Mississippi

Why do we forget in old age?

Neuron photo


One of the most debilitating aspects of advanced age is the accompanying cognitive decline. Patients that experience cognitive deficits are faced with the loss of independence, decreased healthspan, and increased financial burden. Studies suggest that age-related cognitive decline is potentially reversible, but the underlying mechanistic changes have yet to be fully elucidated. Our research program focuses on identifying how reduced neuroendocrine and endocannabinoid signaling impacts the function of neurons, astrocytes, and the supporting vasculature in the aging brain. Using genetic and pharmacological tools, we are able to manipulate these signals and examine how learning and memory is affected, along with a variety of other behavioral responses. We then examine the ensuing structural, biochemical, and genetic changes within the brain to understand which signaling cascades are contributing to the observed alterations in behavior. We also explore the neuroprotective potential of exogenous endocrine and cannabinoid signals in vitro and in vivo. Together, we hope to uncover pharmacological targets that may delay or avert the onset of age-related cognitive decline.


NIH: R15AG059142-01 “The Influence of IGF-1 on Astrocytic Regulation of Learning and Memory”


NIH: P30GM122733-01 “COBRE Phase III Transitional Center”